EDA2R

Function

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.

Cellular localization

• Membrane
• Single-pass type III membrane protein

Alternative names

TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080, EDA2R, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor

Database links

swissprot:Q9HAV5 omim:300276 genbank:AAQ89953 entrezGene:60401