EDEM1
Function
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.
Sequence Similarities
Belongs to the glycosyl hydrolase 47 family.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
Alternative names
EDEM, KIAA0212, EDEM1, ER degradation-enhancing alpha-mannosidase-like protein 1