Ednra
Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
Tissue Specificity
Predominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Endothelin-1 receptor, Endothelin receptor type A, ET-A, ET-AR