EFNA4
Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Sequence Similarities
Belongs to the ephrin family.
Tissue Specificity
Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
Cellular localization
- Isoform 1
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Isoform 2
- Secreted
Alternative names
EPLG4, LERK4, EFNA4, Ephrin-A4, EPH-related receptor tyrosine kinase ligand 4, LERK-4