EFNB2

Function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus.

Post-translational modifications

Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.

Sequence Similarities

Belongs to the ephrin family.

Tissue Specificity

Lung and kidney.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Cell junction
• Adherens junction

Alternative names

EPLG5, HTKL, LERK5, EFNB2, Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, HTK ligand, LERK-5, HTK-L

Database links

swissprot:P52799 omim:300035 omim:600527 swissprot:P98172 entrezGene:1947 entrezGene:1948