EGF

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

Involvement in disease

Hypomagnesemia 4

HOMG4

A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).

Tissue specificity

Expressed in kidney, salivary gland, cerebrum and prostate.

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

• Pro-epidermal growth factor
• EGF
• EGF

Database links

• entrezGene:1950
• omim:131530
• swissprot:P01133

Target type

Proteins

Primary research area

Oncology

Other research areas

• Immuno-oncology

Molecular weight

133994Da