EGF

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).

Hypomagnesemia 4

HOMG4

A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes.

None

The disease is caused by variants affecting the gene represented in this entry.

O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).

Expressed in kidney, salivary gland, cerebrum and prostate.

• Membrane
• Single-pass type I membrane protein

Pro-epidermal growth factor, EGF

• entrezGene:1950
• omim:131530
• swissprot:P01133

Proteins

Oncology

• Immuno-oncology

133994Da