EGF

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).

Cellular localization

• Membrane
• Single-pass type I membrane protein

Alternative names

Pro-epidermal growth factor, EGF

Database links

swissprot:Q00968 entrezGene:397083

Other research areas

• Immuno-oncology