EHD2
Domain
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Function
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833).
Sequence Similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
Tissue Specificity
Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Membrane
- Caveola
- Peripheral membrane protein
- Cytoplasmic side
- Endosome membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
- Cytosol
- Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes.
Alternative names
PAST2, EHD2, EH domain-containing protein 2, PAST homolog 2