EHD2

The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.

ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833).

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.

Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle.

• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Membrane
• Caveola
• Peripheral membrane protein
• Cytoplasmic side
• Endosome membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cytoplasm
• Cytosol
• Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes.

PAST2, EHD2, EH domain-containing protein 2, PAST homolog 2

• entrezGene:30846
• omim:605890
• swissprot:Q9NZN4

Proteins

Oncology

61161Da