Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.
Belongs to the NSE4 family.
Highly expressed in testis.
EP300-interacting inhibitor of differentiation 3, EID-3, E1A-like inhibitor of differentiation 3, EID-1-like inhibitor of differentiation 3, Non-structural maintenance of chromosomes element 4 homolog B, NS4EB, Non-SMC element 4 homolog B, EID3
Proteins
Immuno-oncology
38168Da
We found 1 product in 1 category