EIF4A1
Function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963).
Sequence Similarities
Belongs to the DEAD box helicase family. eIF4A subfamily.
Cellular localization
- Cytoplasm
- Perinuclear region
- Cell membrane
- Cytoplasm
- Stress granule
- Colocalizes with PKP1 in stress granules following arsenate or hydrogen peroxide treatment.
Alternative names
DDX2A, EIF4A, EIF4A1, Eukaryotic initiation factor 4A-I, eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1