EIF4A1

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963).

Belongs to the DEAD box helicase family. eIF4A subfamily.

• Cytoplasm
• Perinuclear region
• Cell membrane
• Cytoplasm
• Stress granule
• Colocalizes with PKP1 in stress granules following arsenate or hydrogen peroxide treatment.

DDX2A, EIF4A, EIF4A1, Eukaryotic initiation factor 4A-I, eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1

• entrezGene:1973
• omim:602641
• swissprot:P60842

Proteins

Metabolism

46154Da