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EIF4B phospho S406

OverviewProducts

Function

Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Post-translational modifications

Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex.

Alternative names

  • Eukaryotic translation initiation factor 4B
  • eIF-4B
  • EIF4B

Database links

Target type

Proteins

Molecular weight

69151Da