Elafin

Domain

Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins.

Function

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648).

Cellular localization

• Secreted

Alternative names

• WAP3
• WFDC14
• PI3
• WAP3
• WFDC14
• Elafin
• Elastase-specific inhibitor
• Peptidase inhibitor 3
• Protease inhibitor WAP3
• Skin-derived antileukoproteinase
• WAP four-disulfide core domain protein 14
• ESI
• PI-3
• SKALP

Database links

• entrezGene:5266
• omim:182257
• swissprot:P19957

Target type

Proteins

Primary research area

Oncology

Molecular weight

12270Da