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ELANE

Function

Medullasin modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Capable of killing E.coli; probably digests outer membrane protein A (ompA) in E.coli (PubMed:10947984).

Sequence similarities

Belongs to the peptidase S1 family. Elastase subfamily.

Alternative names

  • Neutrophil elastase
  • Elastase-2
  • Leukocyte elastase
  • Ela2
  • Elane

Target type

Proteins

Molecular weight

28648Da