Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984).
Cyclic haematopoiesis
CH
Autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.
None
The disease is caused by variants affecting the gene represented in this entry.
Neutropenia, severe congenital 1, autosomal dominant
SCN1
A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
None
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the peptidase S1 family. Elastase subfamily.
Bone marrow cells. Neutrophil (PubMed:10947984).
Proteins
28518Da
We found 29 products in 3 categories
ab119553
ab272279
Anti-Neutrophil Elastase antibody [EPR22896-31] - BSA and Azide free (Capture)
ab272280
Anti-Neutrophil Elastase antibody [EPR22896-78] - BSA and Azide free (Detector)