ELAVL3

Domain

RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity).

Function

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).

Sequence Similarities

Belongs to the RRM elav family.

Tissue Specificity

Brain specific.

Alternative names

HUC, PLE21, ELAVL3, ELAV-like protein 3, Hu-antigen C, Paraneoplastic cerebellar degeneration-associated antigen, Paraneoplastic limbic encephalitis antigen 21, HuC

Database links

swissprot:Q14576 entrezGene:1996 entrezGene:1995 swissprot:P26378 omim:603458 omim:168360