ELK4

Function

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.

Sequence Similarities

Belongs to the ETS family.

Cellular localization

• Nucleus

Alternative names

SAP1, ELK4, ETS domain-containing protein Elk-4, Serum response factor accessory protein 1, SAP-1, SRF accessory protein 1

Database links

swissprot:P28324 omim:600246 swissprot:Q6GSJ2 entrezGene:2005