ELMO1
Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Post-translational modifications
Phosphorylated by HCK.
Tissue Specificity
Widely expressed, with a higher expression in the spleen and placenta.
Cellular localization
- Cytoplasm
- Cell membrane
- Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
Alternative names
KIAA0281, ELMO1, Engulfment and cell motility protein 1, Protein ced-12 homolog