ELN
Function
Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely.
Post-translational modifications
Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.
Hydroxylated on proline residues.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.
Sequence Similarities
Belongs to the elastin family.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Extracellular matrix of elastic fibers.
Alternative names
Elastin, Tropoelastin, ELN