ELOVL2
Domain
The C-terminal di-lysine motif may confer endoplasmic reticulum localization.
Function
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Pathway
Lipid metabolism; polyunsaturated fatty acid biosynthesis.
Sequence Similarities
Belongs to the ELO family. ELOVL2 subfamily.
Tissue Specificity
Liver and testis.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
ELG3, SSC2, ELOVL2, Very long chain fatty acid elongase 2, 3-keto acyl-CoA synthase ELOVL2, ELOVL fatty acid elongase 2, Elongation of very long chain fatty acids protein 2, Very long chain 3-ketoacyl-CoA synthase 2, Very long chain 3-oxoacyl-CoA synthase 2, ELOVL FA elongase 2