ELOVL3

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Lipid metabolism; polyunsaturated fatty acid biosynthesis.

N-Glycosylated.

Belongs to the ELO family. ELOVL3 subfamily.

Testis.

• Endoplasmic reticulum membrane
• Multi-pass membrane protein

CIG30, ELOVL3, Very long chain fatty acid elongase 3, 3-keto acyl-CoA synthase ELOVL3, Cold-inducible glycoprotein of 30 kDa, ELOVL fatty acid elongase 3, Elongation of very long chain fatty acids protein 3, Very long chain 3-ketoacyl-CoA synthase 3, Very long chain 3-oxoacyl-CoA synthase 3, ELOVL FA elongase 3

• entrezGene:83401
• omim:611815
• swissprot:Q9HB03

Proteins

Metabolism

31500Da