ELP5
Function
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity).
Pathway
tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.
Post-translational modifications
Tyrosine-phosphorylated.
Sequence Similarities
Belongs to the ELP5 family.
Tissue Specificity
Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
C17orf81, DERP6, HSPC002, MSTP071, ELP5, Elongator complex protein 5, Dermal papilla-derived protein 6, S-phase 2 protein