C17orf81

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity).

tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.

Tyrosine-phosphorylated.

Belongs to the ELP5 family.

Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.

• Nucleus
• Cytoplasm

C17orf81, DERP6, HSPC002, MSTP071, ELP5, Elongator complex protein 5, Dermal papilla-derived protein 6, S-phase 2 protein

• entrezGene:23587
• omim:615019
• swissprot:Q8TE02

Proteins

34841Da