EMCN
Function
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
Post-translational modifications
Highly O-glycosylated. Sialic acid-rich glycoprotein.
Tissue Specificity
Expressed in heart, kidney and lung.
Cellular localization
- Isoform 1
- Cell membrane
- Single-pass type I membrane protein
- Membrane
- Single-pass type I membrane protein
- Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.
- Isoform 2
- Secreted
Alternative names
EMCN2, MUC14, EMCN, Endomucin, Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14