EML2
Domain
Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
Function
Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
Sequence Similarities
Belongs to the WD repeat EMAP family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cytoskeleton
- Spindle
- Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle.
Alternative names
EMAP2, EMAPL2, EML2, Echinoderm microtubule-associated protein-like 2, EMAP-2, HuEMAP-2