Entpd1
Function
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.
Post-translational modifications
N-glycosylated.
The N-terminus is blocked.
Palmitoylated on Cys-13; which is required for caveola targeting.
Sequence Similarities
Belongs to the GDA1/CD39 NTPase family.
Cellular localization
- Membrane
- Multi-pass membrane protein
- Membrane
- Caveola
Alternative names
CD39, Cd39, Entpd1, Ectonucleoside triphosphate diphosphohydrolase 1, NTPDase 1, ATP diphosphohydrolase, Ecto-ATP diphosphohydrolase 1, Ecto-apyrase, Lymphoid cell activation antigen, Nucleoside triphosphate diphosphohydrolase 1, ATP-DPH, ATPDase, Ecto-ATPDase 1, Ecto-ATPase 1, NTPDase1