ENTPD2
Function
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.
Sequence Similarities
Belongs to the GDA1/CD39 NTPase family.
Tissue Specificity
Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.
Cellular localization
- Isoform Long
- Cell membrane
- Multi-pass membrane protein
- Isoform Short
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Isoform gamma
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
CD39L1, ENTPD2, Ectonucleoside triphosphate diphosphohydrolase 2, NTPDase 2, CD39 antigen-like 1, Ecto-ATP diphosphohydrolase 2, Ecto-ATPDase 2, Ecto-ATPase 2