ENTPD4
Function
Isoform 1
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452).
Isoform 2
Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally.
Sequence Similarities
Belongs to the GDA1/CD39 NTPase family.
Tissue Specificity
Ubiquitous. Highest expression in testis and lowest in bladder.
Cellular localization
- Isoform 1
- Cytoplasmic vesicle
- Autophagosome membrane
- Multi-pass membrane protein
- Lysosome membrane
- Multi-pass membrane protein
- Isoform 2
- Golgi apparatus membrane
- Multi-pass membrane protein
Alternative names
KIAA0392, LALP70, LYSAL1, ENTPD4, Ectonucleoside triphosphate diphosphohydrolase 4, NTPDase 4, Golgi UDPase, Lysosomal apyrase-like protein of 70 kDa, Uridine-diphosphatase, UDPase