ENTPD5
Function
Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity).
Pathway
Protein modification; protein glycosylation.
Post-translational modifications
N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity.
Sequence Similarities
Belongs to the GDA1/CD39 NTPase family.
Tissue Specificity
Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.
Cellular localization
- Endoplasmic reticulum
- Secreted
Alternative names
CD39L4, PCPH, ENTPD5, Nucleoside diphosphate phosphatase ENTPD5, CD39 antigen-like 4, ER-UDPase, Ectonucleoside triphosphate diphosphohydrolase 5, Guanosine-diphosphatase ENTPD5, Inosine diphosphate phosphatase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, NTPDase 5, GDPase ENTPD5, UDPase ENTPD5