ENTPD6
Function
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:11041856, PubMed:14529283). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:11041856, PubMed:14529283).
Post-translational modifications
The secreted form may be produced by intracellular processing.
N-glycosylated.
Sequence Similarities
Belongs to the GDA1/CD39 NTPase family.
Tissue Specificity
Expressed in most tissues, but predominantly in heart.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
- Secreted
- Cell membrane
- Single-pass type II membrane protein
- Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant.
Alternative names
CD39L2, IL6ST2, ENTPD6, Ectonucleoside triphosphate diphosphohydrolase 6, NTPDase 6, CD39 antigen-like 2