ENTPD8
Domain
The transmembranous domains are involved in regulation of enzyme activity.
Function
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the GDA1/CD39 NTPase family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
UNQ2492/PRO5779, ENTPD8, Ectonucleoside triphosphate diphosphohydrolase 8, E-NTPDase 8, NTPDase 8, NTPDase8