Envelope glycoprotein B
Function
Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
Post-translational modifications
A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.
Sequence Similarities
Belongs to the herpesviridae glycoprotein B family.
Cellular localization
- Virion membrane
- Single-pass type I membrane protein
- Host cell membrane
- Single-pass type I membrane protein
- Host endosome membrane
- Single-pass type I membrane protein
- Host Golgi apparatus membrane
- Single-pass type I membrane protein
- During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Alternative names
Envelope glycoprotein B, gB, UL55