ENY2
Function
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).
Sequence Similarities
Belongs to the ENY2 family.
Cellular localization
- Nucleus
- Nucleoplasm
- Localization at the nuclear pore complex requires NUP153 and TPR.
Alternative names
DC6, ENY2, Transcription and mRNA export factor ENY2, Enhancer of yellow 2 transcription factor homolog