Eomes

Developmental stage

Originally expressed in the trophoectoderm of the blastocyst and later in the extraembryonic ectoderm of the early post-implantation embryo. In the embryo proper, expressed in the posterior part of the epiblast. During gastrulation, extends distally into the primitive streak and nascent mesoderm. Also expressed in the developing forebrain and the olfactory lobes. Expressed at 12.5 dpc and 14.5 dpc in the forebrain.

Function

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

Tissue Specificity

Expressed in CD8+ T-cells.

Cellular localization

• Nucleus

Alternative names

Tbr2, Eomes, Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2

Database links

swissprot:O54839 entrezGene:13813

Other research areas

• Epigenetics
• Immunology & Infectious Disease
• Neuroscience