EPB41L4B
Function
Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927).
Post-translational modifications
May be negatively regulated by phosphorylation.
Tissue Specificity
Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge (PubMed:23664528). Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast (PubMed:14521927).
Cellular localization
- Cytoplasm
- Cell junction
- Tight junction
- Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner.
Alternative names
EHM2, LULU2, EPB41L4B, Band 4.1-like protein 4B, Erythrocyte membrane protein band 4.1-like 4B, FERM-containing protein CG1, Protein EHM2