Epcam

Function

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity).

Post-translational modifications

Glycosylation at Asn-198 is crucial for protein stability.

Sequence Similarities

Belongs to the EPCAM family.

Cellular localization

• Lateral cell membrane
• Single-pass type I membrane protein
• Cell junction
• Tight junction
• Colocalizes with CLDN7 at the lateral cell membrane and tight junction.

Alternative names

CD326, Tacstd1, Epcam, Epithelial cell adhesion molecule, Ep-CAM, Epithelial glycoprotein 314, Protein 289A, Tumor-associated calcium signal transducer 1, EGP314, mEGP314

Database links

swissprot:Q99JW5 entrezGene:17075

Other research areas

• Immuno-oncology