Epha1
Developmental stage
In myogenic progenitor cells, expressed during the acquisition of muscle stem cell properties, from 18.5 dpc to adulthood.
Function
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Post-translational modifications
Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1 (By similarity).
Ubiquitinated.
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Tissue Specificity
Preferentially expressed in epithelial cells including skin, kidney, liver and thymus (PubMed:11519828, PubMed:18802966). Expressed in myogenic progenitor cells (PubMed:27446912).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Esk, Epha1, Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK