Epha6
Function
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Ehk-2, Ehk2, Epha6, Ephrin type-A receptor 6, EPH homology kinase 2, EHK-2