EPHX1
Function
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity).
Involvement in disease
In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls.
Variations in EPHX1 gene non-coding regions have been observed in a patient with hypercholanemia. The pathogenicity of these variants has not been confirmed.
Sequence Similarities
Belongs to the peptidase S33 family.
Tissue Specificity
Found in liver.
Cellular localization
- Microsome membrane
- Single-pass type III membrane protein
- Endoplasmic reticulum membrane
- Single-pass type III membrane protein
Alternative names
EPHX, EPOX, EPHX1, Epoxide hydrolase 1, Epoxide hydratase, Microsomal epoxide hydrolase, mEH