EPN2
Domain
The NPF repeat domain is involved in EPS15 binding.
The DPW repeat domain is involved in AP-2 and clathrin binding.
Function
Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Post-translational modifications
Ubiquitinated.
Sequence Similarities
Belongs to the epsin family.
Tissue Specificity
Highest expression is found in brain. Detected at lower levels in lung and liver.
Cellular localization
- Cytoplasm
- Cytoplasmic vesicle
- Clathrin-coated vesicle
- In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
Alternative names
KIAA1065, EPN2, Epsin-2, EPS-15-interacting protein 2