Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
Belongs to the EPO/TPO family.
Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Erythropoietin, Epo
Proteins
Oncology
21365Da
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ab276979