EPOP/C17orf96

The BC-box, which mediates binding to the elongin BC complex.

Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation.

• Nucleus
• Chromosome
• Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs).

C17orf96, PRR28, EPOP, Elongin BC and Polycomb repressive complex 2-associated protein, Proline-rich protein 28

• entrezGene:100170841
• swissprot:A6NHQ4

Proteins

Epigenetics

39322Da