EPPK1
Domain
Plectin repeats are important for the binding to keratin and VIM and controls intermediate filament networks organization.
Function
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:23398049, PubMed:27206504). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:23398049, PubMed:27206504). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity).
Sequence Similarities
Belongs to the plakin or cytolinker family.
Tissue Specificity
Expressed in epithelial cells of liver, small intestine, colon, salivary glands, stomach and appendix.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell junction
- Hemidesmosome
- Cell junction
- Tight junction
- Cell projection
- Apicolateral cell membrane
- Basolateral cell membrane
- Cell junction
- May move dynamically from bundling intermediate filaments in the cytoplasm or at the cell periphery and reinforcing them (PubMed:23398049). Decorates the keratin intermediate filaments (IF) network and partially that of vimentin (PubMed:15671067).
Alternative names
EPIPL, EPPK1, Epiplakin, 450 kDa epidermal antigen