EPS15L1
Function
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Post-translational modifications
Phosphorylated on tyrosine residues by EGFR.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Nucleus
- Membrane
- Coated pit
- Localized to plasma membrane coated pits.
Alternative names
EPS15R, EPS15L1, Epidermal growth factor receptor substrate 15-like 1, Eps15-related protein, Eps15R