EPX
Function
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Involvement in disease
Eosinophil peroxidase deficiency
EPXD
A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the peroxidase family. XPO subfamily.
Cellular localization
- Cytoplasmic granule
- Cytoplasmic granules of eosinophils.
Alternative names
EPER, EPO, EPP, EPX, Eosinophil peroxidase