ERAP2
Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the peptidase M1 family.
Tissue Specificity
Ubiquitously expressed. Highly expressed in spleen and leukocytes.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
Alternative names
LRAP, ERAP2, Endoplasmic reticulum aminopeptidase 2, Leukocyte-derived arginine aminopeptidase, L-RAP