ERBB3 phospho Y1289

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.

Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

In the muscle, expression localizes to the synaptic sites of muscle fibers.

• Membrane
• Single-pass type I membrane protein

Receptor tyrosine-protein kinase erbB-3, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3

• entrezGene:13867
• swissprot:Q61526

Proteins

Oncology

147613Da