Ereg

Developmental stage

Expressed in 7-day-old embryos with levels then falling to very low or undetectable amounts. Not detected in adult.

Function

Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (By similarity). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357).

Cellular localization

• Epiregulin
• Secreted
• Extracellular space
• Proepiregulin
• Cell membrane
• Single-pass type I membrane protein

Alternative names

Proepiregulin, Ereg

Database links

swissprot:Q61521