ERN2

Function

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Post-translational modifications

Autophosphorylated.

Sequence Similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Cellular localization

• Endoplasmic reticulum membrane
• Single-pass type I membrane protein

Alternative names

IRE2, ERN2, Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, Ire1-beta, hIRE2p, IRE1b

Database links

swissprot:Q76MJ5 entrezGene:10595 omim:604034 swissprot:O75460 entrezGene:2081