ESCO1
Domain
The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process.
Function
Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15958495, PubMed:18614053). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3 (PubMed:18614053).
Post-translational modifications
Phosphorylated during mitosis, when associated with chromosomes.
Sequence Similarities
Belongs to the acetyltransferase family. ECO subfamily.
Tissue Specificity
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
Cellular localization
- Nucleus
- Chromosome
- Nuclear at interphase, associated with chromosomes during mitosis.
Alternative names
EFO1, KIAA1911, ESCO1, N-acetyltransferase ESCO1, CTF7 homolog 1, Establishment factor-like protein 1, Establishment of cohesion 1 homolog 1, EFO1p, hEFO1, ECO1 homolog 1, ESO1 homolog 1