ESPL1
Function
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Post-translational modifications
Autocleaves. This function, which is not essential for its protease activity, is unknown.
Phosphorylated by CDK1. There are 8 Ser/Thr phosphorylation sites. Among them, Ser-1126 phosphorylation is the major site, which conducts to the enzyme inactivation.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
ESP1, KIAA0165, ESPL1, Separin, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase