Separase

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

Autocleaves. This function, which is not essential for its protease activity, is unknown.

Phosphorylated by CDK1. There are 8 Ser/Thr phosphorylation sites. Among them, Ser-1126 phosphorylation is the major site, which conducts to the enzyme inactivation.

• Cytoplasm
• Nucleus

ESP1, KIAA0165, ESPL1, Separin, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase

• entrezGene:9700
• omim:604143
• swissprot:Q14674

Proteins

Epigenetics

233175Da