ESR2 phospho S105
Domain
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).
Isoform 2
Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Involvement in disease
Ovarian dysgenesis 8
ODG8
An autosomal dominant form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
None
The disease may be caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
Sequence Similarities
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Tissue Specificity
Isoform 1
Expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors.
Isoform 2
Expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus.
Isoform 4
Expressed in the testis.
Isoform 5
Expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus.
Isoform 6
Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
Cellular localization
- Nucleus
Alternative names
ESTRB, NR3A2, ESR2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2
Database links
Other research areas
- Epigenetics